Dataset Information
Whole genome bisufite sequencing of smoking and non-smoking mother-child pairsBisufite sequencing, RNA-seq and ChIP-Seq data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001000455 | EGA |
REPOSITORIES: EGA
Publications
Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.
Molecular systems biology 20160324 3
Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype-related DNA methylation changes. Di ...[more]
