Identification of point mutations, expression perturbations, and gene fusions in T-cell acute lymphoblastic leukemia by RNA-seq
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ABSTRACT:
PROVIDER: EGAS00001000536 | EGA |
REPOSITORIES: EGA
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Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.
Atak Zeynep Kalender ZK Gianfelici Valentina V Hulselmans Gert G De Keersmaecker Kim K Devasia Arun George AG Geerdens Ellen E Mentens Nicole N Chiaretti Sabina S Durinck Kaat K Uyttebroeck Anne A Vandenberghe Peter P Wlodarska Iwona I Cloos Jacqueline J Foà Robin R Speleman Frank F Cools Jan J Aerts Stein S
PLoS genetics 20131219 12
RNA-seq is a promising technology to re-sequence protein coding genes for the identification of single nucleotide variants (SNV), while simultaneously obtaining information on structural variations and gene expression perturbations. We asked whether RNA-seq is suitable for the detection of driver mutations in T-cell acute lymphoblastic leukemia (T-ALL). These leukemias are caused by a combination of gene fusions, over-expression of transcription factors and cooperative point mutations in oncogen ...[more]
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