Dataset Information
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001000667 | EGA |
REPOSITORIES: EGA
Publications
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
Nature genetics 20140202 3
Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p ...[more]
