Genomics

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The Berlin (BLN) panel of glioblastoma cell lines: RNAseq of human gliomasphere cell lines and matched parental tumors

ABSTRACT: We generated a panel of nine glioma stem-like cell lines under serum-free cell culture conditions from human glioblastoma samples. In addition to clinical annotation, MR imaging and histological characterization of the parental tumor, as well as xenograft studies of tumorigenecity, transcriptomic profiling of tumor/cell line pairs by RNA sequencing has been performed.

PROVIDER: EGAS00001001167 | EGA |

REPOSITORIES: EGA

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Publications

Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.

Schulze Heuling Eva E   Knab Felix F   Radke Josefine J   Eskilsson Eskil E   Martinez-Ledesma Emmanuel E   Koch Arend A   Czabanka Marcus M   Dieterich Christoph C   Verhaak Roel G RG   Harms Christoph C   Euskirchen Philipp P  

Molecular cancer research : MCR 20170201 5

Promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is a critical biomarker in glioblastoma (GBM), as treatment decisions and clinical trial inclusion rely on its accurate assessment. However, interpretation of results is complicated by poor interassay reproducibility as well as a weak correlation between methylation status and expression levels of MGMT. This study systematically investigates the influence of tumor purity on tissue subjected to MGM  ...[more]

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