Genomics

Dataset Information

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560 whole-genome sequenced breast cancers

ABSTRACT: A comprehensive characterisation and analysis of 560 human breast cancers through genome-wide approaches including genomics, transcriptomics and epigenomics.

PROVIDER: EGAS00001001178 | EGA |

REPOSITORIES: EGA

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Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nik-Zainal Serena S   Davies Helen H   Staaf Johan J   Ramakrishna Manasa M   Glodzik Dominik D   Zou Xueqing X   Martincorena Inigo I   Alexandrov Ludmil B LB   Martin Sancha S   Wedge David C DC   Van Loo Peter P   Ju Young Seok YS   Smid Marcel M   Brinkman Arie B AB   Morganella Sandro S   Aure Miriam R MR   Lingjærde Ole Christian OC   Langerød Anita A   Ringnér Markus M   Ahn Sung-Min SM   Boyault Sandrine S   Brock Jane E JE   Broeks Annegien A   Butler Adam A   Desmedt Christine C   Dirix Luc L   Dronov Serge S   Fatima Aquila A   Foekens John A JA   Gerstung Moritz M   Hooijer Gerrit K J GK   Jang Se Jin SJ   Jones David R DR   Kim Hyung-Yong HY   King Tari A TA   Krishnamurthy Savitri S   Lee Hee Jin HJ   Lee Jeong-Yeon JY   Li Yilong Y   McLaren Stuart S   Menzies Andrew A   Mustonen Ville V   O'Meara Sarah S   Pauporté Iris I   Pivot Xavier X   Purdie Colin A CA   Raine Keiran K   Ramakrishnan Kamna K   Rodríguez-González F Germán FG   Romieu Gilles G   Sieuwerts Anieta M AM   Simpson Peter T PT   Shepherd Rebecca R   Stebbings Lucy L   Stefansson Olafur A OA   Teague Jon J   Tommasi Stefania S   Treilleux Isabelle I   Van den Eynden Gert G GG   Vermeulen Peter P   Vincent-Salomon Anne A   Yates Lucy L   Caldas Carlos C   van't Veer Laura L   Tutt Andrew A   Knappskog Stian S   Tan Benita Kiat Tee BK   Jonkers Jos J   Borg Åke Å   Ueno Naoto T NT   Sotiriou Christos C   Viari Alain A   Futreal P Andrew PA   Campbell Peter J PJ   Span Paul N PN   Van Laere Steven S   Lakhani Sunil R SR   Eyfjord Jorunn E JE   Thompson Alastair M AM   Birney Ewan E   Stunnenberg Hendrik G HG   van de Vijver Marc J MJ   Martens John W M JW   Børresen-Dale Anne-Lise AL   Richardson Andrea L AL   Kong Gu G   Thomas Gilles G   Stratton Michael R MR  

Nature 20160502 7605

We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended  ...[more]

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