Genomics

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124

MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells


ABSTRACT: Despite the established role of the transcription factor MYC in cancer, little is known about the involvement of lncRNAs in mediating MYC's function. Here we have intersected RNA-sequencing data from MYC-inducible cell lines, from a cohort of 91 mature B-cell lymphomas and from sorted germinal-center B-cells. By this approach, we identified 13 lncRNAs differentially expressed in IG-MYC-positive Burkitt lymphoma and regulated by MYC in the model cell lines. Among them we focused on a lncRNA that we named MINCR, showing a strong correlation with MYC expression in MYC-positive lymphomas and in pancreatic ductal adenocarcinomas. RNAi experiments showed that MINCR controls cellular viability by influencing the expression of MYC-regulated cell cycle genes. Finally we provide evidences that down-regulation of AURKA, AURKB and CTD1 may explain the reduction in cellular proliferation observed upon MINCR knock-down. We therefore suggest that MINCR acts as a modulator of MYC transcriptional control of cell cycle genes.

ORGANISM(S): Homo sapiens  

PROVIDER: EGAS00001001199 | EGA |

REPOSITORIES: EGA

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MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.

Doose Gero G   Haake Andrea A   Bernhart Stephan H SH   López Cristina C   Duggimpudi Sujitha S   Wojciech Franziska F   Bergmann Anke K AK   Borkhardt Arndt A   Burkhardt Birgit B   Claviez Alexander A   Dimitrova Lora L   Haas Siegfried S   Hoell Jessica I JI   Hummel Michael M   Karsch Dennis D   Klapper Wolfram W   Kleo Karsten K   Kretzmer Helene H   Kreuz Markus M   Küppers Ralf R   Lawerenz Chris C   Lenze Dido D   Loeffler Markus M   Mantovani-Löffler Luisa L   Möller Peter P   Ott German G   Richter Julia J   Rohde Marius M   Rosenstiel Philip P   Rosenwald Andreas A   Schilhabel Markus M   Schneider Markus M   Scholz Ingrid I   Stilgenbauer Stephan S   Stunnenberg Hendrik G HG   Szczepanowski Monika M   Trümper Lorenz L   Weniger Marc A MA   Hoffmann Steve S   Siebert Reiner R   Iaccarino Ingram I  

Proceedings of the National Academy of Sciences of the United States of America 20150908 38


Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long noncoding RNAs (lncRNAs), on MYC ability to influence the cellular transcriptome. Here, we have intersected RNA-sequencing data from two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression. We identified 13 lncRNAs differentially expressed in IG-MYC-positive Burkitt  ...[more]

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