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SNP genotyping data in genes related to trace element homeostasis

ABSTRACT: In this study we provide data regarding sample charactheristics and genotypes in 150 human samples of European origin for SNPs located around genes related to metal homeostasis. SNPs were genotyped with the Illumina VeraCode technology (192-plex format). The genotyped SNPs were used to identify quantitative trait loci in the same samples. Data referring to the quantification of 18 micronutrients, the expression levels of 90 genes and the protein abundances of 40 proteins related to metal homeostasis in the same samples are directly available as supplementary material in the publication of this study.

PROVIDER: EGAS00001001292 | EGA |

REPOSITORIES: EGA

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Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.

Engelken Johannes J Espadas Guadalupe G Mancuso Francesco M FM Bonet Nuria N Scherr Anna-Lena AL Jímenez-Álvarez Victoria V Codina-Solà Marta M Medina-Stacey Daniel D Spataro Nino N Stoneking Mark M Calafell Francesc F Sabidó Eduard E Bosch Elena E

Molecular biology and evolution 20151117 3

Essential trace elements possess vital functions at molecular, cellular, and physiological levels in health and disease, and they are tightly regulated in the human body. In order to assess variability and potential adaptive evolution of trace element homeostasis, we quantified 18 trace elements in 150 liver samples, together with the expression levels of 90 genes and abundances of 40 proteins involved in their homeostasis. Additionally, we genotyped 169 single nucleotide polymorphism (SNPs) in ...[more]

PMID: 26582562

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