Integrated genomic characterization of IDH1 mutant Glioma malignant progression
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PROVIDER: EGAS00001001588 | EGA |
REPOSITORIES: EGA
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Integrated genomic characterization of IDH1-mutant glioma malignant progression.
Bai Hanwen H Harmancı Akdes Serin AS Erson-Omay E Zeynep EZ Li Jie J Coşkun Süleyman S Simon Matthias M Krischek Boris B Özduman Koray K Omay S Bülent SB Sorensen Eric A EA Turcan Şevin Ş Bakırcığlu Mehmet M Carrión-Grant Geneive G Murray Phillip B PB Clark Victoria E VE Ercan-Sencicek A Gulhan AG Knight James J Sencar Leman L Altınok Selin S Kaulen Leon D LD Gülez Burcu B Timmer Marco M Schramm Johannes J Mishra-Gorur Ketu K Henegariu Octavian O Moliterno Jennifer J Louvi Angeliki A Chan Timothy A TA Tannheimer Stacey L SL Pamir M Necmettin MN Vortmeyer Alexander O AO Bilguvar Kaya K Yasuno Katsuhito K Günel Murat M
Nature genetics 20151130 1
Gliomas represent approximately 30% of all central nervous system tumors and 80% of malignant brain tumors. To understand the molecular mechanisms underlying the malignant progression of low-grade gliomas with mutations in IDH1 (encoding isocitrate dehydrogenase 1), we studied paired tumor samples from 41 patients, comparing higher-grade, progressed samples to their lower-grade counterparts. Integrated genomic analyses, including whole-exome sequencing and copy number, gene expression and DNA me ...[more]
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