A new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation
Ontology highlight
ABSTRACT: Hepatocellular adenomas (HCA) are benign liver tumors divided in molecular subtypes characterized by mutations inactivating HNF1A, activating β-catenin or the IL-6/JAK/STAT inflammatory pathway. Molecular analyses of 533 HCA developed in 411 patients identified a new tumor subgroup with Sonic Hedgehog pathway activation due to focal deletions creating INHBE promoter/GLI1 fusions.
PROVIDER: EGAS00001002091 | EGA |
REPOSITORIES: EGA
ACCESS DATA
