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The identification of genetic vulnerabilities in head and neck cancers for the development of novel therapies

ABSTRACT: CRISPR/Cas9 lethality screens in a set of Asian head and neck cancer cell lines to identify novel targets.

PROVIDER: EGAS00001002204 | EGA |

REPOSITORIES: EGA

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EGAS00001002204-sc-2020-01-15T09:24:14Z - samples

Project description:CRISPR/Cas9 lethality screens in a set of Asian head and neck cancer cell lines to identify novel targets. . This dataset contains all the data available for this study on 2020-01-15.

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The identification of genetic vulnerabilities in head and neck cancers for the development of novel treatments.

Project description:The global cancer burden is expected to double by the year 2030 and this will disproportionately affect the Asian continent. Head and neck squamous cell carcinoma (HNSCC) is endemic in Asia. It is the sixth most common cancer worldwide and the second most common in Malaysia, with approximately 600,000 new cases per year globally. Longterm survival remains less than 50%, underscoring the need for better therapeutic strategies. In this proposal we aim to bring new technological advancements in the identification of critical genes in HNSCC and the identification of compounds for the development of new therapies in HNSCC. We propose to genomically characterise 16 unique Asian H&N cancer cell lines, to classify sub groups where identification of essential genes that can be targeted for tumor control can be applied in a more rational way. Further, we propose to use zebrafish, an established drug discovery platform to identify promising pathway-specific compounds that could be further studied using CRISPR/Cas9 lethality screens and biological models to better identify novel therapeutic strategies to combat this major health problem in Asia.

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