Genomics

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Genomic landscape of IG-MYC positive Burkitt lymphoma with precursor B-cell immunophenotype.

ABSTRACT: As part of the ICGC, the ICGC MMML-Seq project performed whole genome sequencing of a rare Burkitt lymphoma subtype with precursor B-cell immunophenotype. Analysis were performed in concordance with the guidelines of the ICGC.

PROVIDER: EGAS00001002968 | EGA |

REPOSITORIES: EGA

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IG-<i>MYC</i> <sup>+</sup> neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

Wagener Rabea R   López Cristina C   Kleinheinz Kortine K   Bausinger Julia J   Aukema Sietse M SM   Nagel Inga I   Toprak Umut H UH   Seufert Julian J   Altmüller Janine J   Thiele Holger H   Schneider Christof C   Kolarova Julia J   Park Jeongbin J   Hübschmann Daniel D   Murga Penas Eva M EM   Drexler Hans G HG   Attarbaschi Andishe A   Hovland Randi R   Kjeldsen Eigil E   Kneba Michael M   Kontny Udo U   de Leval Laurence L   Nürnberg Peter P   Oschlies Ilske I   Oscier David D   Schlegelberger Brigitte B   Stilgenbauer Stephan S   Wössmann Wilhelm W   Schlesner Matthias M   Burkhardt Birgit B   Klapper Wolfram W   Jaffe Elaine S ES   Küppers Ralf R   Siebert Reiner R  

Blood 20181003 21

The <i>WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue</i> notes instances of Burkitt lymphoma/leukemia (BL) with IG-<i>MYC</i> rearrangement displaying a B-cell precursor immunophenotype (termed herein "preBLL"). To characterize the molecular pathogenesis of preBLL, we investigated 13 preBLL cases (including 1 cell line), of which 12 were analyzable using genome, exome, and targeted sequencing, imbalance mapping, and DNA methylation profiling. In 5 patients with reads across  ...[more]

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