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Profiling of Peritoneal Metastases from Gastric Adenocarcinoma Identified Molecular Subtypes

ABSTRACT: Peritoneal carcinomatosis (PC) occurs frequently in gastric adenocarcinoma (GAC) patients and confers poor prognosis. Multiplex profiling of primary GACs has been insightful but the underpinnings of PC’s development/progression remain largely unknown. Here we characterized exome/transcriptome/immune landscapes of PC cells from 43 patients.

PROVIDER: EGAS00001003180 | EGA |

REPOSITORIES: EGA

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Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response.

Wang Ruiping R Song Shumei S Harada Kazuto K Ghazanfari Amlashi Fatemeh F Badgwell Brian B Pizzi Melissa Pool MP Xu Yan Y Zhao Wei W Dong Xiaochuan X Jin Jiangkang J Wang Ying Y Scott Ailing A Ma Lang L Huo Longfei L Vicente Diego D Blum Murphy Mariela M Shanbhag Namita N Tatlonghari Ghia G Thomas Irene I Rogers Jane J Kobayashi Makoto M Vykoukal Jody J Estrella Jeannelyn Santiano JS Roy-Chowdhuri Sinchita S Han Guangchun G Zhang Shaojun S Mao Xizeng X Song Xingzhi X Zhang Jianhua J Gu Jian J Johnson Randy L RL Calin George Adrian GA Calin George Adrian GA Peng Guang G Lee Ju-Seog JS Hanash Samir M SM Futreal Andrew A Wang Zhenning Z Wang Linghua L Ajani Jaffer A JA

Gut 20190606 1

<h4>Objective</h4>Peritoneal carcinomatosis (PC) occurs frequently in patients with gastric adenocarcinoma (GAC) and confers a poor prognosis. Multiplex profiling of primary GACs has been insightful but the underpinnings of PC's development/progression remain largely unknown. We characterised exome/transcriptome/immune landscapes of PC cells from patients with GAC aiming to identify novel therapeutic targets.<h4>Design</h4>We performed whole-exome sequencing (WES) and whole transcriptome sequenc ...[more]

PMID: 31171626

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