Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GWAS Steroid Sensitive Nephrotic Syndrome

ABSTRACT: GWAS on a cohort of European ancestry comprising 422 SSNS cases and 5,642 matched controls.

PROVIDER: EGAS00001003607 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomic analysis of frontal fibrosing alopecia

Project description:We undertook transcriptome profiling with RNA-sequencing of scalp skin from seven cases of European ancestry and seven matched controls.

2019-01-29 | GSE125733 | GEO

GENEVA GWAS of Prematurity and its Complications - European Ancestry

Project description:GENEVA GWAS of Prematurity and its Complications - European Ancestry

| PRJNA75461 | ENA

ALIVE Cohort Smokescreen GWAS

Project description:ALIVE Cohort Smokescreen GWAS

| PRJNA420792 | ENA

ALIVE Cohort Smokescreen GWAS

Project description:ALIVE Cohort Smokescreen GWAS

| PRJNA420791 | ENA

Multi-ancestry genetic analysis of gene regulation in coronary artery prioritizes disease risk loci

Project description:Genome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotype information to identify quantitative trait loci (QTL) for gene expression and splicing in coronary arteries obtained from 138 ancestrally diverse Americans.

2023-11-14 | GSE225650 | GEO

Chronic Renal Insufficiency Cohort (CRIC) GWAS

Project description:Chronic Renal Insufficiency Cohort (CRIC) GWAS

| PRJNA171879 | ENA

Activation of the Interferon Pathway is Dependent upon Autoantibodies in African-American SLE Patients, but not in European-American SLE Patients

Project description:Systemic lupus erythematosus (SLE) is a heterogeneous disease which leads to different levels of serum autoantibodies to RNA-binding proteins (anti-RBP) and interferon-Î± (IFN-Î±), which plays an important pathogenic role in SLE, between European-American (EA) and African-American (AA) patients. We aimed to explore how IFN-related gene expression pathways differ in patients according to their ancestry and anti-RBP profile Whole blood from 33 female SLE patients and 16 matched controls from EA and AA ancestral backgrounds was analyzed through Affymetrix Gene 1.0 ST gene expression arrays and the data were further studied through Ingenuity Pathways Analysis for canonical pathway comparison. An independent replication cohort of more than 100 SLE patient samples and 30 controls was used to test the hypotheses generated by the microarray data, using qPCR to quantify gene expression.

2013-11-15 | E-GEOD-50635 | biostudies-arrayexpress

CRC GWAS on the Spanish population

Project description:Genome-wide association study performed on the EPICOLON2 cohort, comprising colorectal cancer cases and matched controls of Spanish origin.

| EGAS00001003633 | EGA

Ancestry-Linked IL-10 Signaling and Macrophage Activation Modulate Fibroblast Responses to Oxidative Stress in a PEG-Based Microphysiological System

Project description:Fibroblast responses to injury are shaped by cytokine signaling and macrophage activation, yet the extent to which these pathways vary across individuals, and how ancestry associated immune differences influence fibrosis risk, remains poorly understood. Here, we developed a poly(ethylene glycol) (PEG)-based hydrogel microphysiological system to model fibroblast-macrophage interactions following oxidative stress and integrate donor-specific immune signals using matched macrophages and serum. Circulating monocytes from individuals of self-reported African American ancestry exhibited higher expression of CCL4 and increased serum IL10, whereas those from European ancestry donors showed elevated OXER1 expression. Within the hydrogel, oxidative stress reduced fibroblast number while inducing Ki67 and p16. Exogenous TGFbeta1 enhanced fibroblast survival and collagen 3 production but did not independently increase alpha smooth muscle actin (alphaSMA). Anti-inflammatory macrophages promoted fibroblast activation through mechanisms resistant to TGFbeta receptor inhibition. Incorporating donor-derived macrophages and serum revealed that cultures from individuals of European ancestry demonstrated higher fibroblast alphaSMA and p16 expression, despite lower systemic IL10 levels. Pharmacologic inhibition of IL10 further increased alphaSMA, particularly in European ancestry derived cultures, identifying IL10 as a key protective signal limiting fibroblast activation. This hydrogel system provides a platform for dissecting inter-individual immune variation and identifying mechanisms underlying ancestry associated fibrosis risk.

2026-01-06 | MSV000100385 | MassIVE

Homo sapiens

Project description:GENEVA GWAS of Prematurity and its Complications - European Ancestry

| PRJNA75463 | ENA