The role of the mammalian SWI/SNF chromatin remodeling complex in neuroendocrine prostate cancer

ABSTRACT: We sought to determine the effects of SMARCA4 and SMARCA2 depletion in prostate cancer cell lines. We performed siRNA-mediated knock-down of SMARCA4 and SMARCA2 in an androgen-sensitive (LNCaP) cell line and in a castration-resistant prostate cancer (CRPC)-adenocarcinoma cell line (22Rv1) and compared global transcriptional alterations using RNA-seq.

PROVIDER: EGAS00001004177 | EGA |

REPOSITORIES: EGA