Genomics

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Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms


ABSTRACT: Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically heterogeneous neoplasms. We used a multi-omics approach to uncover the molecular factors underlying this heterogeneity and derive a potential disease classification. Transcriptomic analysis of 84 primary PNEN specimens, drawn from two cohorts (n = 36 and 48), identified four subgroups with distinct molecular profiles. Whole-exome sequencing revealed subgroup-enriched mutational differences.

PROVIDER: EGAS00001005024 | EGA |

REPOSITORIES: EGA

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