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Whole-genome sequencing of a census-based elderly cohort of Brazilians

ABSTRACT: This project generated a high-coverage WGS dataset of 1,000+ highly admixed elderly from a census-based cohort from SÃƒÂ£o Paulo, Brazil (SABE Study). Current Brazilian population results from admixture of Iberian Europeans, West and East Africans and Native Americans, and from 19th century onwards other groups from Europe, Asian and Middle East arrived in Brazil. The phase 1 includes BAM files from 1,171 individuals, described in pre-print "Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (SÃƒÂ£o Paulo, Brazil)" (DOI: 10.1101/2020.09.15.298026).

PROVIDER: EGAS00001005052 | EGA |

REPOSITORIES: EGA

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Exomic variants of an elderly cohort of Brazilians in the ABraOM database.

Naslavsky Michel Satya MS Yamamoto Guilherme Lopes GL de Almeida Tatiana Ferreira TF Ezquina Suzana A M SAM Sunaga Daniele Yumi DY Pho Nam N Bozoklian Daniel D Sandberg Tatiana Orli Milkewitz TOM Brito Luciano Abreu LA Lazar Monize M Bernardo Danilo Vicensotto DV Amaro Edson E Duarte Yeda A O YAO Lebrão Maria Lúcia ML Passos-Bueno Maria Rita MR Zatz Mayana M

Human mutation 20170503 7

Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia and yet still underrepresented in genomic databanks. We hereby present a collection of exomic variants from 609 elderly Brazilians in a census-based cohort (SABE609) with comprehensive phenotyping. Variants were deposited in ABraOM (Online Archive of Brazilian Mutations), a Web-based public database. Population representative phenotype and genotype repositories are essential for variant interpretation through alle ...[more]

PMID: 28332257

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