Dataset Information

SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]

ABSTRACT: CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding, which was associated with a loss of recognition and functional responses by CD8+ T cells isolated from HLA-matched COVID-19 patients. Our findings highlight the capacity of SARS-CoV-2 to subvert CD8+ T cell surveillance through sporadically emerging escape mutations in MHC- I restricted viral epitopes.

PROVIDER: EGAS00001005060 | EGA |

REPOSITORIES: EGA

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SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.

Agerer Benedikt B Koblischke Maximilian M Gudipati Venugopal V Montaño-Gutierrez Luis Fernando LF Smyth Mark M Popa Alexandra A Genger Jakob-Wendelin JW Endler Lukas L Florian David M DM Mühlgrabner Vanessa V Graninger Marianne M Aberle Stephan W SW Husa Anna-Maria AM Shaw Lisa Ellen LE Lercher Alexander A Gattinger Pia P Torralba-Gombau Ricard R Trapin Doris D Penz Thomas T Barreca Daniele D Fae Ingrid I Wenda Sabine S Traugott Marianna M Walder Gernot G Pickl Winfried F WF Thiel Volker V Allerberger Franz F Stockinger Hannes H Puchhammer-Stöckl Elisabeth E Weninger Wolfgang W Fischer Gottfried G Hoepler Wolfgang W Pawelka Erich E Zoufaly Alexander A Valenta Rudolf R Bock Christoph C Paster Wolfgang W Geyeregger René R Farlik Matthias M Halbritter Florian F Huppa Johannes B JB Aberle Judith H JH Bergthaler Andreas A

Science immunology 20210301 57

CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation, IFN-γ production and cytotoxic activity of CD8+ T ...[more]

PMID: 33664060

Dataset Information

SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]

Publications

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8<sup>+</sup> T cell responses.

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