Oncogenic cooperation between the TCF7-SPI1 fusion and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia.

ABSTRACT: In this study we investigate the role of TCF7-SPI1 fusions, more specifically in cooperation with RAS mutations. We make use of patients samples. This study contains paired-end RNA sequencing of the patients, Oxford Nanopore Technologies (ONT) sequencing, single cell RNA sequencing and RNA sequencing of treatment with inhibitors of these samples.

PROVIDER: EGAS00001005097 | EGA |

REPOSITORIES: EGA