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Platelet response in aspirin adherent pregnant women

ABSTRACT: We conducted an unbiased genome-wide assessment of genomic factors that may influence response to low-dose aspirin in pregnant women at high risk of pre-eclampsia in two pregnancy cohorts: Liverpool (n=91) and Dublin (n=91). We applied UK Axiom microarray technology for GWAS investigations. We specified tight phenotyping with COX-selective urinary 11-dehydrothromboxane B2 (pg/mg creatinine) and accounted for adherence/platelet exposure to aspirin by detection of aspirinÃ¢Â€Â™s principal urinary metabolite, SUA, with nuclear magnetic resonance (NMR).

PROVIDER: EGAS00001005188 | EGA |

REPOSITORIES: EGA

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