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Gremlin 1 + fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

ABSTRACT: Although cross-species transcriptional analysis has been generated for DCs37, transcriptomic conservation between mouse and human FRCs at single-cell resolution has been unclear. To test whether GREM1+ FRCs might also play a role in DC homeostasis in humans, we performed scRNA-seq of CD45Ã¢Â€Â“PDPN+ stromal cells, as well as CD45+CD11c+ immune cells from healthy human LNs of three donors.

PROVIDER: EGAS00001006211 | EGA |

REPOSITORIES: EGA

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Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

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