Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

ABSTRACT: Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycemic traits. However, little is known about the function of the zinc finger transcription factor RREB1 in glucose homeostasis or how changes in its expression and/or function influences diabetes risk.

PROVIDER: EGAS00001006314 | EGA |

REPOSITORIES: EGA