In silico drug target prediction for melanoma

ABSTRACT: The in silico single gene deletion step was adapted to simulate the knock-out of all targets of a drug on an objective function such as growth or energy balance. Based on publicly available and in-house large scale transcriptomic data, metabolic models for melanoma were reconstructed, enabling the prediction of 28 candidate drugs and estimating their respective efficacy.

PROVIDER: EGAS00001006463 | EGA |

REPOSITORIES: EGA