Tracing early predictors of glioma evolution under therapy

ABSTRACT: Clonal evolution drives cancer progression and therapeutic resistance. Recent studies revealed divergent longitudinal trajectories in gliomas, but early molecular traits steering post-treatment cancer evolution remain unclear. We analyzed sequencing data of 544 initial-recurrent adult diffuse glioma pairs to identify genomic and transcriptomic early predictors of tumor evolution in each molecular subtype.

PROVIDER: EGAS00001006894 | EGA |

REPOSITORIES: EGA