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Molecular analysis of cancer genomes in children with Lynch syndrome: exploring causal associations

ABSTRACT: Lynch syndrome (LS) predisposes to cancer in adulthood and is caused by heterozygous germline variants in a mismatch repair (MMR) gene. Recent studies show an increased prevalence of LS among children with cancer, suggesting a causal relationship. For LS-spectrum (LSS) cancers, including high-grade gliomas and colorectal cancer, causality has been supported by typical MMR-related tumor characteristics, but for non-LSS cancers, causality is unclear. This dataset contains 5 patients with Lynch Syndrome from the INFORM registry.

PROVIDER: EGAS00001007146 | EGA |

REPOSITORIES: EGA

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Molecular analysis of cancer genomes in children with Lynch syndrome: exploring causal associations

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