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Genome-Wide Association Analysis of Serum Iron in the InCHIANTI and BLSA

ABSTRACT:

The aim of this study was to identify gene(s) associated with serum iron concentrations. This dataset contains the results from a meta-analysis of 1919 subjects from the InCHIANTI and Baltimore Longitudinal Study of Aging (BLSA). Both studies are population based prospective studies that evaluate the contributors of normal aging.

PROVIDER: phs000215.v1.p1 | EGA |

REPOSITORIES: EGA

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Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study.

Ferrucci L L Bandinelli S S Benvenuti E E Di Iorio A A Macchi C C Harris T B TB Guralnik J M JM

Journal of the American Geriatrics Society 20001201 12

<h4>Background</h4>Older patients are often referred to geriatricians because of complaints of progressive difficulties in walking. The diagnostic and therapeutic approach to these patients is complex. Multiple physiologic subsystems may influence the ability to walk, and no standard criteria are currently available to establish whether these subsystems are functioning within the normal range. To address this lack of knowledge we conducted the InCHIANTI study.<h4>Objective</h4>To identify measur ...[more]

PMID: 11129752

Publication: 1/5

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Project description:<p>Version 1</p> <p>The aim of this study was to identify gene(s) associated with serum iron concentrations. This dataset contains the results from a meta-analysis of 1919 subjects from the InCHIANTI and Baltimore Longitudinal Study of Aging (BLSA). Both studies are population based prospective studies that evaluate the contributors of normal aging.</p> <p>Version 2</p> <p>We performed genome wide analysis of 93 circulating biomarkers in the InCHIANTI study of 1210 individuals, after imputation from the 1000 genomes project.</p>

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Gene expression analysis of canine osteosarcoma tissue from patients with normal and increased serum alkaline phosphatase concentration

Project description:Serum alkaline phosphatase (ALP) concentration is a prognostic factor for osteosarcoma in multiple studies, though its biological significance remains incompletely understood. To determine whether gene expression patterns differed in osteosarcoma from patients with differing serum ALP concentrations, microarray analysis was performed on 18 primary osteosarcoma samples and six osteosarcoma cell lines from dogs with normal and increased serum ALP concentration. No differences in gene expression patterns were noted between tumors or cell lines with differing serum ALP concentration using a gene-specific two-sample t-test. Using a more sensitive empirical Bayes procedure, DCUN1D1 was increased in both the tissue and cell lines of the normal ALP group. Using QPCR, differences in DCUN1D1 expression between the two groups failed to reach significance. The homogeneity of gene expression patterns of osteosarcoma associated differing serum ALP concentrations are consistent with previous studies suggesting serum ALP concentration is not associated with intrinsic differences of osteosarcoma cells. A total of 18 canine primary osteosarcoma tumor samples were used in this study. 9 tumor samples were from patients having a normal serum alkaline phosphatase concentration. 9 tumor samples were from patients having an increased serum alkaline phosphatase concentration. There were no reference tissues or controls used in this study.

2014-11-19 | E-GEOD-63476 | biostudies-arrayexpress

Gene expression analysis of canine osteosarcoma tissue from patients with normal and increased serum alkaline phosphatase concentration

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