Dataset Information

Genetic Epidemiology of Refractive Error in the KORA (Kooperative Gesundheitsforschung in der Region Augsburg) Study

ABSTRACT:

KORA ("Kooperative Gesundheitsforschung in der Region Augsburg" which translates as "Cooperative Health Research in the Region of Augsburg") is a population based study of adults randomly selected from 430,000 inhabitants living in Augsburg and 16 surrounding counties in Germany. The collection was done in 4 separate groups from 1984-2001 (S1-S4). One of the KORA groups, S3/F3, will be utilized for our GWAS because it is the only group with refractive error (RE) measurements. Consequent to informed consent, each of the surveys sampled subjects from ten strata according to age (range 25-74 years) and sex (equal ratio) with a minimum stratum size of > 400 subjects. In the KORA S3 study 4,856 subjects were studied between 1994 and 1995, and 3,006 individuals from S3 returned for follow up between 2003 and 2005 (S3/F3). For this refractive error study, we are including 1,981 subjects from S3/F3 (mean age 55.7, range 35-84). For each subject, eyeglass prescriptions were measured in addition to an evaluation by the Nikon Retinomax. Subjects with predisposing medical conditions, i.e., connective tissue disorders, and ocular conditions i.e., cataract and corneal opacities, that might predispose them to refractive error will not be included for genotyping.

Whole genome association genotyping will be performed to determine common alleles that contribute to the variation of the quantitative trait of refractive error.

PROVIDER: phs000303.v1.p1 | EGA |

REPOSITORIES: EGA

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Publications

Prolonged recruitment efforts in health surveys: effects on response, costs, and potential bias.

Holle Rolf R Hochadel Matthias M Reitmeir Peter P Meisinger Christa C Wichmann H Erich HE

Epidemiology (Cambridge, Mass.) 20061101 6

<h4>Background</h4>In health surveys, considerable effort and expense are invested to achieve a high response proportion and thereby to reduce selection bias. We investigated the interrelation of recruitment efforts and expense with potential nonresponse bias based on data from a large health survey.<h4>Methods</h4>In a population-based health survey, a stratified sample of 6640 residents of the Augsburg (Germany) region was selected, of whom 4261 attended the main study between October 1999 and ...[more]

PMID: 17003684

Publication: 1/5

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Dataset Information

Genetic Epidemiology of Refractive Error in the KORA (Kooperative Gesundheitsforschung in der Region Augsburg) Study

Publications

Prolonged recruitment efforts in health surveys: effects on response, costs, and potential bias.

Similar Datasets

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