Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bivariate genome-wide association analysis of BMI and WHR in Chinese twins

ABSTRACT: We presented a bivariate twin study to determine the genetic variants associated with body mass index and waist hip ratio, and explore the obesity-related pathway in Northern Han Chinese.Genomic DNA was extracted from whole peripheral blood. Genotyping of 278 eligible DNA samples from 139 DZ twin pairs were performed by using the Infinium Omni2.5Exome-8v1.2 genotyping BeadChips (Illumina Inc, San Diego, USA).

INSTRUMENT(S): unspecified

ORGANISM(S): Homo Sapiens

SUBMITTER: Qingdao University

PROVIDER: PRJEB23749 | EVA | 2017-12-06

REPOSITORIES: EVA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	Plus_BM_vcf6.vcf.gz	Vcf
	Plus_BM_vcf6.vcf.gz.tbi	Vcf

Items per page:

1 - 2 of 2

Similar Datasets

Epigenome analysis of female identical twins

Project description:Genome wide DNA methylation profiling of blood samples from eight female identical twins of Han Chinese for forensic age prediction, age 21 to 32. The Illumina Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 485,000 CpGs at a single-nucleotide resolution. Samples included 8 pairs of identical female twins of Han Chinese.

2015-12-08 | GSE65638 | GEO

Whole Sequencing Of The Mitochondrial Genome Of Breast Tumor Tissue In Mexican-Mestizo Postmenopausal Women, With Different Body Mass Index

Project description:Mitochondrial and oxidative stress have been related to obesity and breast cancer, and this cancer is more frequent and more aggressive in postmenopausal women with obesity. To investigate if Mexican-Mestizo postmenopausal women with breast cancer and obesity presented different somatic mutations in the mitochondrial DNA (mtDNA) when compared to women with normal body mass index.

2019-03-31 | GSE125801 | GEO

ASA-750K array genotyping of Northern Han Chinese and Southern Han Chinhttps://www.ncbi.nlm.nih.gov/geo/subsese

Project description:ASA-750K array genotyping of Northern Han Chinese and Southern Han Chinhttps://www.ncbi.nlm.nih.gov/geo/subsese

| PRJNA595143 | ENA

Epigenome analysis of female identical twins

2015-12-08 | E-GEOD-65638 | biostudies-arrayexpress

Somatic copy number variants in monozygotic twins and elderly single-born individuals

Project description:We perfomed copy number analysis of young and old monozygotic twin pairs and young and old single-born individuals to identify somatic copy number changes that occur with age in blood DNA. DNA from peripheral blood was run on Illumina genotyping arrays and the R and B-allele-frequency data were used to identify somatic copy number events

2011-12-16 | E-GEOD-34467 | biostudies-arrayexpress

Identification of loci and signaling pathways associated with ITP using pooling genome-wide association study in Han Chinese

Project description:Immune thrombocytopenia (ITP) is an autoimmnue bleeding disorder characterized by low platelet count. To identify susceptibility loci for disease progression of ITP, we performed this genome-wide association study using DNA pools of 200 ITP cases and 200 controsl in Han Chinese. Performing GWAS on pools of DNA samples is an effective strategy to reduce the costs of studies and pooling DNA has been shown to be an efficient method to select candidate susceptibility loci for follow-up by individual genotyping.

2016-01-12 | GSE76744 | GEO

Peripheral blood gene expression profiles in obese subjects without metabolic syndrome.

Project description:Background: Understanding molecular basis involved in obesity is a crucial first step in developing therapeutic strategies against excess in body weight gain Objective: The purpose of our study was to assess if obesity possess unique peripheral blood gene expression profiles, in a pilot study.

2016-03-15 | E-MTAB-3017 | biostudies-arrayexpress

Project description:Obesity SNP genotyping

| PRJNA449974 | ENA

Maternal Stress and Genomic Variation

Project description:Custom Affymetrix SNP used to assay 24 mothers for desired variants. Data processed using the Affymetrix SNP Genotyping Console (Version 4.2, Affymetrix Inc., Santa Clara, CA, USA).

2017-11-30 | GSE107512 | GEO

Epigenome-wide Association Study of Physical Activity and Physiological Parameters in Discordant Monozygotic Twins

Project description:An epigenome-wide association study (EWAS) was performed on buccal cells from monozygotic-twins (MZ) reared together as children, but who live apart as adults. Cohorts of twin pairs were used to investigate associations between neighborhood walkability and objectively measured physical activity (PA) levels. Due to dramatic cellular epigenetic sex differences, male and female MZ twin pairs were analyzed separately to identify differential DNA methylation regions (DMRs). A priori comparisons were made on MZ twin pairs discordant on body mass index (BMI), PA levels, and neighborhood walkability. In addition to direct comparative analysis to identify specific DMRs, a weighted gene coexpression network analysis (WGCNA) was performed to identify DNA methylation sites associated with the physiological traits of interest. The pairs discordant in PA levels had epigenetic alterations that correlated with reduced metabolic parameters (i.e., BMI). The DNA methylation sites are associated with over fifty genes previously found to be specific to vigorous PA, metabolic risk factors, and sex. Combined observations demonstrate that behavioral factors, such as physical activity, appear to promote systemic epigenetic alterations that impact metabolic risk factors. The epigenetic DNA methylation sites and associated genes identified provide insight into PA impacts on metabolic parameters and the etiology of obesity.

2022-12-01 | GSE216387 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data