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Morpheus model of spatio-temporal YAP/Hippo pathway activation during liver regeneration

ABSTRACT: Morpheus model of spatio-temporal YAP/Hippo pathway activation during liver regeneration

SUBMITTER: Lutz Brusch

PROVIDER: 760 | FAIRDOMHub | 2020-11-27

REPOSITORIES: FAIRDOMHub

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Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration.

Meyer Kirstin K Morales-Navarrete Hernan H Seifert Sarah S Wilsch-Braeuninger Michaela M Dahmen Uta U Tanaka Elly M EM Brusch Lutz L Kalaidzidis Yannis Y Zerial Marino M

Molecular systems biology 20200201 2

The mechanisms of organ size control remain poorly understood. A key question is how cells collectively sense the overall status of a tissue. We addressed this problem focusing on mouse liver regeneration. Using digital tissue reconstruction and quantitative image analysis, we found that the apical surface of hepatocytes forming the bile canalicular network expands concomitant with an increase in F-actin and phospho-myosin, to compensate an overload of bile acids. These changes are sensed by the ...[more]

PMID: 32090478

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