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Expression profiling of peripheral blood mononuclear cells in normal controls and patients with Parkinson's disease

ABSTRACT: Autophagy is a highly conserved degradation pathway whereby not only cytosolic components but also aberrant proteins are sequestered within double-membraned vesicles. Parkinson's disease (PD) is pathologically characterized by accumulation of phosphorylated α-synuclein in the neuronal cytoplasm and its accumulation occurs in the peripheral autonomic nervous system as well as the central nervous system. In the brains of patients with PD, abnormal autophagy is known to occur and be involved with neurodegeneration. To investigate abnormal autophagy in peripheral blood mononuclear cells (PBMC) in the patients with PD, we performed whole transcriptome analysis of PBMC obtained from 9 normal controls and 10 patients with PD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100054 | GEO | 2017/07/27

SECONDARY ACCESSION(S): PRJNA390560

REPOSITORIES: GEO

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Transcriptomic profiling of peripheral blood mononuclear cells from patients with ParkinsonM-bM-^@M-^Ys disease and control subjects.

Project description:To get insight into systemic molecular events associated with ParkinsonM-bM-^@M-^Ys disease (PD), an age-related neurodegenerative disorder, we compared gene expression patterns of peripheral blood mononuclear cells (PBMC) derived from elderly healthy controls and from PD patients. Transcriptomic profiling of patients with ParkinsonM-bM-^@M-^Ys disease and control subjects. RNA were extracted from peripheral mononuclear blood cells and were hybridized on 4x44k Agilent expression microarrays.

2012-03-20 | E-GEOD-22491 | biostudies-arrayexpress

Transcriptomic profiling of peripheral blood mononuclear cells from patients with Parkinson's disease and control subjects

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2019-09-25 | GSE49126 | GEO

Transcriptomic profiling of peripheral blood mononuclear cells from patients with Parkinson’s disease and control subjects.

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2012-03-20 | GSE22491 | GEO

Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures

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mRNA expression profiling of mitochondrial subunits in subjects with Parkinson’s disease

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Expression data from rat regenerating livers after autonomic nervous system is disrupted

2010-12-18 | GSE26138 | GEO

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| phs001595 | dbGaP

Expression data from rat regenerating livers after autonomic nervous system is disrupted

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2010-12-18 | E-GEOD-26138 | biostudies-arrayexpress

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