Genomics

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Discovery of naturally occurring ESR1 mutations during acquisition of resistance to endocrine therapy in widely used estrogen receptor positive breast cancer cell lines [RNA-Seq]


ABSTRACT: We report the first discovery of naturally occurring ESR1Y537C and ESR1Y537S mutations in MCF7 and SUM44 ESR1-positive cell-lines after acquisition of resistance to long-term-estrogen-deprivation (LTED) and subsequent resistance to fulvestrant (ICIR).

ORGANISM(S): Homo sapiens

PROVIDER: GSE100075 | GEO | 2018/01/12

SECONDARY ACCESSION(S): PRJNA390636

REPOSITORIES: GEO

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