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The prefrontal cortex microRNA expression in mice offspring caused by glyphosate exposure during pregnancy and lactation

ABSTRACT: In this study, the miRNAs expression pattern in prefrontal cortex (PFC) of postnatal day (PND) 28 mice offsprings which were exposured by glyphosate-based herbicide (GBH) during pregnancy and lactation was investigated. MiRNA microarray had detected 55 upregulated and 19 downregulated miRNAs in the PND28 mice offsprings' PFC. Overall design: In this study, the isolated total RNA taken from two pooled samples of two groups, was used to acquire expression profiles, and the result shows 53 differentially-expressed miRNAs, some of them are known to be involved in brain development or the pathogenesis of neurodevelopmental disorders, indicate that dysregulated expression of miRNAs may be involved in the mechanism of glyphosate-induced neurotoxicity.

INSTRUMENT(S): Exiqon miRCURY LNA microRNA array, 7th generation [miRBase v18, condensed Probe_ID version]


PROVIDER: GSE100079 | GEO | 2017-06-16



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Differential microRNA expression in the prefrontal cortex of mouse offspring induced by glyphosate exposure during pregnancy and lactation.

Ji Hua H   Xu Linhao L   Wang Zheng Z   Fan Xinli X   Wu Lihui L  

Experimental and therapeutic medicine 20171221 3

Glyphosate is the active ingredient in numerous herbicide formulations. The role of glyphosate in neurotoxicity has been reported in human and animal models. However, the detailed mechanism of the role of glyphosate in neuronal development remains unknown. Recently, several studies have reported evidence linking neurodevelopmental disorders (NDDs) with gestational glyphosate exposure. The current group previously identified microRNAs (miRNAs) that are associated with the etiology of NDDs, but th  ...[more]

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