Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Retina injury timecourse

ABSTRACT: Sprague-Dawley rat retina post-injury and control samples Keywords = Gliosis, CNS injury

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE1001 | GEO | 2004/03/29

SECONDARY ACCESSION(S): PRJNA87055

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of injured retinas from male Sprague-Dawley rats at 4 hours, 1, 3, 7 and 30 days post-injury

Project description:Sprague-Dawley rat retina post-injury and control samples

2007-10-26 | E-GEOD-1001 | biostudies-arrayexpress

Comparative proteomic analyses of normal human retina, gliotic PVR retina and human Müller glia

Project description:This study has applied proteomic methodologies to compare protein expression profiles of gliotic and normal human retina as well as established human Müller stem cell lines. It is hoped that this investigation may provide insight into mechanisms of gliosis and also aid studies focusing on endogenous regeneration of the retina following disease or injury

2018-09-06 | PXD008485 | Pride

Transcription profiling of rat astrocytes in culture and from human optic nerve to identify acutely expressed genes during CNS injury and their expression in cultured astrocytes

Project description:A robust set of CNS transcript changes was defined by comparing microarray data that describe the injury response of the rat retina [Vazquez-Chona et al., IOVS 2004; GSE1001], brain [Matzilevich et al., J Neurosci Res 2002; GSE1911], and spinal cord [Di Giovanni et al., Ann Neurol 2003; GDS63]. We determined the CNS injury genes that were expressed in cultured astrocytes from rat cortex [GSM34300] and from human optic nerve head [Yang et al., Physiol Genomics 2004; GDS532].

2008-06-11 | E-GEOD-1928 | biostudies-arrayexpress

acute genes during CNS injury and their expression in cultured astrocytes

2005-07-01 | GSE1928 | GEO

Transcriptome profiling of the rat retina following ischemia-reperfusion injury

Project description:Transcriptomics has played valuable roles in deciphering differences between normal and diseased conditions at the molecular level. Herein is presented a transcriptome profile of ischemia-reperfusion (I/R) injury in adult Sprague-Dawley rat model and control group. Following acute I/R induction, a pool of the rats’ retinas at 12hr post I/R was made. RNA sequencing was performed on both the model and the control groups, followed by their transcriptomic analyses. Sample validation and quality control were done in accordance with standard protocols. Comparison of the sequenced data revealed significant variations in genes expression between the I/R model and their sham counterparts. These differentially expressed genes may provide valuable information to understanding the molecular mechanisms underlying retinal cell dysfunction, cell death and structure collapse in adult rats, and may help characterize or develop therapeutic interventions for visual impairment.

2022-05-01 | GSE130610 | GEO

Transcriptome profiling of the rat retina following ischemia-reperfusion injury

Project description:Transcriptome profiling of the rat retina following ischemia-reperfusion injury

| PRJNA540770 | ENA

Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury

Project description:To explore the impact of targeting IL-10 signaling, tibialis anterior (TA) VML injuries were created and then treated in Sprague Dawley rats using an autologous minced muscle regenerative medicine repair strategy in combination with delayed exogenous IL-10 delivery. We then performed gene expression profiling analysis using data obtained from RNA-seq from rat muscles (n=4 for IL-10 treatment, n=4 for PBS control , and n=4 for uninjured control) at day 14 post injury

2022-06-26 | GSE206823 | GEO

Gene expression profiling of vasoregression in the retina

Project description:Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in retinal neurodegeneration, we used microarray techniques to compare gene expression profiles in this new model before and after retinal vasoregression. Differential gene expression was validated by quantitative RT-PCR, Western blot and immunofluorescence. Of the 374 genes regulated more than twofold, the MHC class II invariant chain CD74 yielded the strongest upregulation, and was allocated to activated microglial cells close to the vessels undergoing vasoregression. Pathway clustering identified genes of the immune system, inflammatory signaling, and components of the complement cascade upregulated during vasoregression. Furthermore, macroglial cells were markedly activated. Together, our data suggest that glial cells involved in retinal immune response participate in the initiation of vasoregression in the retina. we used microarray techniques to define gene expression profiles related to vasoregression in a rat ciliopathy model. PKD-2-247 rats (TGR) and male Sprague-Dawley (SD) rats at 1 and 3 months of age were used for the analysis. SD rats served as control in this study. Three individual rat retinae (n=3) in each group were analysed.

2011-03-15 | E-GEOD-20967 | biostudies-arrayexpress

Rattus norvegicus

Project description:Transcriptome of radiation-induced esophageal injury in Sprague Dawley Rat

| PRJNA600134 | ENA

Gene expression profile on the penile tissue of erectile dysfunction (ED) in cavernous nerve injury (CNI) RAT model

Project description:(Erectile dysfunction) ED during the radical prostatectomy (RP) treatment is caused by surgical injury of the cavernous nerve which is the final neuronal pathways of penile erection. We performed microarray experiment focused on theto understanding the gene signature alteration in the corporal cavernous tissue of the CNI-induced ED rat model. A total of 6 adult male Sprague-Dawley rats were randomly divided into two groups, sham operation (n=3) and bilateral CN resection (n=3) group. At 12 weeks after CN resection, penile tissue was harvested and microarray experiment was performed.

2012-12-31 | E-GEOD-31247 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data