Transcriptomics,Genomics

Dataset Information

24

Time-course global miRNA expression profiling on lung fibroblasts isolated from untreated, bleomycin-treated and silica-treated mice


ABSTRACT: Lung fibroblasts play a pivotal role in pulmonary fibrosis, a devastating lung diseases, by producing extracellular matrix. MicroRNAs (miRNAs) suppress a lot of genes posttranscriptionally, but the dynamics and the role of miRNAs in activated lung fibroblasts in fibrotic lung has been poorly understood. To elucidate these problems, we performed global miRNA expression profiling of lung fibroblasts of bleomycin- and silica-induced fibrotic lungs Overall design: Global miRNA expression profile of lung fibroblasts isolated from untreated, bleomycin-treated and silica-treated mice on days 7, 14 and 28 post-treatment was generated using Ion Total RNA-seq Kit v2 and Ion PGM sequencer.

INSTRUMENT(S): Ion Torrent PGM (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Shigeyuki Shichino  

PROVIDER: GSE100115 | GEO | 2018-11-20

REPOSITORIES: GEO

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Publications

Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis.

Souma Kunihiko K   Shichino Shigeyuki S   Hashimoto Shinichi S   Ueha Satoshi S   Tsukui Tatsuya T   Nakajima Takuya T   Suzuki Hiroshi I HI   Shand Francis H W FHW   Inagaki Yutaka Y   Nagase Takahide T   Matsushima Kouji K  

Scientific reports 20181109 1


Lung fibroblasts play a pivotal role in pulmonary fibrosis, a devastating lung disease, by producing extracellular matrix. MicroRNAs (miRNAs) suppress numerous genes post-transcriptionally; however, the roles of miRNAs in activated fibroblasts in fibrotic lungs remain poorly understood. To elucidate these roles, we performed global miRNA-expression profiling of fibroblasts from bleomycin- and silica-induced fibrotic lungs and investigated the functions of miRNAs in activated lung fibroblasts. Cl  ...[more]

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