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EcR-dependent gene expression in MB neurons at the onset of axon pruning

ABSTRACT: This study identifies genes that show EcR-dependent gene expression in MB neurons at the onset of axon pruning. Keywords: nuclear receptor gene regulation

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE10013 | GEO | 2008/06/01

SECONDARY ACCESSION(S): PRJNA109069

REPOSITORIES: GEO

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Transcription profiling of Drosophila EcR-dependent gene expression in MB neurons at the onset of axon pruning

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2008-06-18 | E-GEOD-10013 | biostudies-arrayexpress

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Project description:Genomic analysis of axon pruning in Drosophila mushroom body neurons

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Drosophila melanogaster

Project description:EcR-dependent gene expression in MB neurons at the onset of axon pruning

| PRJNA109069 | ENA

Actin dependent astrocytic infiltration is a key step for axon defasciculation during remodeling

Project description:A strocytes are essential for synapse formation, maturation and plasticity, yet their function during developmental neuronal remodeling is largely unknown To identify astrocytic molecules required for axon pruning of mushroom body ( γ neurons in Drosophi la we profile d the expression of astrocytes before ( and after ( remodeling. F ocus ing on genes enriched in larval astrocytes we identified 12 genes that are required in astrocytes, for axon pruning including the F actin regulat ors Arpc1 and form3 Interestingly, perturbing astrocytic actin dynamics did not affect their gross morphology migration or TGF β secretion In contrast, actin dynamics was required for astrocyte infiltration into the axon bundle at the onset of pruning. Remarkably, decreasing axonal adhesion facilitated the infiltration of Arpc1 KD astrocytes, and suppressed the pruning defect driven by the astrocytic perturbation Together, our findings suggest that actin dependent astrocytic infiltration is a key step in axon pruning thus promoting our understanding of neuron glia interactions during remodeling

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Project description:Comparisons between EcR mutant midgut and a reference control sample from mixed-stage normal midgut Keywords = Drosophila, ecdysone, network, genomic, microarray, organogenesis, EcR, midgut, central nervous system, salivary gland, epidermis, imaginal disc, development Keywords: other

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EcR mutant midgut comparison

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