Transcriptomics,Genomics

Dataset Information

160

Molecular characterisation of sorted populations of DRG and TG ganglia neurons


ABSTRACT: Sensory neurons were extracted from the dorsal root or trigeminal ganglia of AdvGFP transgenic mice and their molecular profile analysed via RNA-seq. Overall design: RNA-seq of naïve FACS-purified DRG and TG neurons

INSTRUMENT(S): Illumina HiSeq 4000 (Mus musculus)

SUBMITTER: Franziska Denk 

PROVIDER: GSE100175 | GEO | 2017-10-11

SECONDARY ACCESSION(S): PRJNA390912

REPOSITORIES: GEO

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Publications

The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons.

Lopes Douglas M DM   Denk Franziska F   McMahon Stephen B SB  

Frontiers in molecular neuroscience 20170926


The dorsal root ganglia (DRG) and trigeminal ganglia (TG) are clusters of cell bodies of highly specialized sensory neurons which are responsible for relaying information about our environment to the central nervous system. Despite previous efforts to characterize sensory neurons at the molecular level, it is still unknown whether those present in DRG and TG have distinct expression profiles and therefore a unique molecular fingerprint. To address this question, we isolated lumbar DRG and TG neu  ...[more]

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