Transcriptomics,Genomics

Dataset Information

36

Transcriptional Signature Associated with Early Rheumatoid Arthritis and Healthy Individuals at high risk to develop the disease.


ABSTRACT: To identify biomarkers and transcriptomic pathways associated with the development of rheumatoid arhtritis, we performed a transcriptional analysis using a hole genome microarray to demostrate that a specific transcriptional signature is associated with the development of RA, and it exists since the beginning and presence of auto-antibodies against citrulinated proteins. Overall design: Whole blood total RNA was obtained from non-treated early RA patients with <1 year of evolution as well as from healthy first-degree relatives of patients with RA (FDR) classified as ACCP+ and ACCP- according to their serum levels of antibodies against cyclic citrullinated peptides. Cy3-labeled complementary RNA (cRNA) was synthetized and hybridized to high-density microarrays, analyzed in genespring and functional categories were assigned to a specific transcriptome identified in subjects with RA and FDR ACCP positive. Specific signaling pathways for genes associated to RA were identified.

INSTRUMENT(S): Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)

SUBMITTER: Noe Macias-Segura  

PROVIDER: GSE100191 | GEO | 2017-06-20

SECONDARY ACCESSION(S): PRJNA390940

REPOSITORIES: GEO

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Publications


Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early rheumatoid arthritis (RA) and subjects at high risk. Several biomarker candidates for early RA are proposed.Whole blood total RNA was obtained from non-treated early RA patients with <1 year of evolution as well as from healthy first-degree relat  ...[more]

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