Dataset Information


The Australian Mammographic Density Twins and Sisters Study - DNA methylation data

ABSTRACT: DNA methylation data for 479 women from 130 families including 66 monozygotic twin pairs, 66 dizygotic twin pairs and 215 sisters of twins. Overall design: Genomic DNA was extracted from dried blood spots. DNA was sodium bisulfite converted using the EZ DNA Methylation-Gold protocol. Epigenome-wide methylation was assessed using the Infinium HumanMethylation450 BeadChip arrays

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

ORGANISM(S): Homo Sapiens

SUBMITTER: John Hopper  

PROVIDER: GSE100227 | GEO | 2017-06-21



Dataset's files

Action DRS
GSE100227_RAW.tar Raw
GSE100227_normalized_data.txt.gz Txt
GSE100227_unmethylated_and_methylated_singal_intensities.txt.gz Txt
filelist.txt Txt
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Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women.

Li Shuai S   Wong Ee Ming EM   Joo JiHoon E JE   Jung Chol-Hee CH   Chung Jessica J   Apicella Carmel C   Stone Jennifer J   Dite Gillian S GS   Giles Graham G GG   Southey Melissa C MC   Hopper John L JL  

Twin research and human genetics : the official journal of the International Society for Twin Studies 20151103 6

The disease- and mortality-related difference between biological age based on DNA methylation and chronological age (Δage) has been found to have approximately 40% heritability by assuming that the familial correlation is only explained by additive genetic factors. We calculated two different Δage measures for 132 middle-aged female twin pairs (66 monozygotic and 66 dizygotic twin pairs) and their 215 sisters using DNA methylation data measured by the Infinium HumanMethylation450 BeadChip arrays  ...[more]

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