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Gene expression profile of ADM, ductal and acinar cells in the setting of pancreatitis

ABSTRACT: In order to compare the gene expression profile of acinar-to-ductal metaplasia (ADM), ductal and acinar cells in the setting of pancreatitis, which were obtained by laser-capture microdissection (LMD) from frozen sections of wild type mice pancreata 2 days after caerulein administration, we performed microarray analysis. ADM has an intermediate property between ductal and acinar cells in the setting of pancreatitis, and Cxcr4 mRNA which is expressed in multipotent pancreatic progenitors, were up-regulated in ADM compared with ductal cells or acinar cells. Notably, in consistent with our immunostaining data, Dclk1 mRNA was highly expressed in ADM cells compared with ductal and acinar cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE100270 | GEO | 2017/06/21

SECONDARY ACCESSION(S): PRJNA391186

REPOSITORIES: GEO

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Mus musculus

Project description:Gene expression profile of ADM, ductal and acinar cells in the setting of pancreatitis

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Project description:This study describes a novel function for the ST6GAL1 sialyltransferase in promoting acinar to ductal metaplasia (ADM). ST6GAL1 activity facilitates ADM by reprogramming acinar cells into a more progenitor-like state.

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