Transcriptomics,Genomics

Dataset Information

37

Placental gene expression profiling for the identification of subtypes of human fetal growth restriction


ABSTRACT: Fetal growth restriction (FGR) is a heterogeneous disorder of pregnancy associated with pathologically low fetal and neonatal weights. We hypothesized that FGR consists of multiple placental subtypes, similar to what we have observed in preeclampsia. To address this hypothesis, we assembled a fetal growth-focused human placental microarray data set (N=97) consisting of 20 new normotensive suspected FGR samples (below), in addition to term controls (N=26) and hypertensive suspected FGR samples (N=51) from GSE75010. Overall design: FGR was defined as an SGA infant (birthweight <10th percentile for gestational age and sex based on a Canadian growth reference) with signs of placental insufficiency, and 20 normotensive suspected FGR placentas were purchased from a biobank. Genome-wide mRNA expression was assessed by Affymetrix Human Gene 1.0 ST Array chips and aggregated with samples from GSE75010. Unsupervised clustering analysis was applied to the combined dataset (N=97), followed by pathway enrichment analysis and correlative analysis with clinical information and histological lesions in these placentas.

REANALYSIS of: GSE75010GSE98224

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

ORGANISM(S): Homo sapiens  

SUBMITTER: Brian Cox  

PROVIDER: GSE100415 | GEO | 2018-10-13

REPOSITORIES: GEO

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Publications

Placental transcriptional and histologic subtypes of normotensive fetal growth restriction are comparable to preeclampsia.

Gibbs Isaac I   Leavey Katherine K   Benton Samantha J SJ   Grynspan David D   Bainbridge Shannon A SA   Cox Brian J BJ  

American journal of obstetrics and gynecology 20181009 1


BACKGROUND:Infants born small for gestational age because of pathologic placenta-mediated fetal growth restriction can be difficult to distinguish from those who are constitutionally small. Additionally, even among fetal growth-restricted pregnancies with evident placental disease, considerable heterogeneity in clinical outcomes and long-term consequences has been observed. Gene expression studies of fetal growth-restricted placentas also have limited consistency in their findings, which is like  ...[more]

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