Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Xray induced expression profile change in sensitive vs resistant embryos

ABSTRACT: stage 9-11 embryos are sensitive to x-ray induced cell death, while stage 13-15 embryos are highly resistant. The gene expression changes induced by x-ray in sensitve vs resistant embryos appear to be qualitatively different. Keywords: repeat sample

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE1005 | GEO | 2004/06/29

SECONDARY ACCESSION(S): PRJNA87059

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling of Drosophila x-ray sensitive and resistant embryos after exposure to x-rays

Project description:stage 9-11 embryos are sensitive to x-ray induced cell death, while stage 13-15 embryos are highly resistant. The gene expression changes induced by x-ray in sensitve vs resistant embryos appear to be qualitatively different.

2007-07-06 | E-GEOD-1005 | biostudies-arrayexpress

Human BRAF-V600E melanoma cell lines drug sensitive vs drug resistant

Project description:aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline

2014-04-21 | GSE49430 | GEO

Human BRAF-V600E melanoma cell lines drug sensitive vs drug resistant

Project description:aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline Two condition experiment: two BRAF-V600E mutant cell lines (drug sensitive - parental baseline) vs two derived sublines after chronic exposure to the MEK inhibitor trametinib (drug resistant) are compared

2014-04-21 | E-GEOD-49430 | biostudies-arrayexpress

Expression data from mouse preimplantation cloned embryos

2013-04-05 | GSE41358 | GEO

Proteome analysis of mouse Wdr74-knockout embryos

Project description:Mouse Wdr74-knockout embryos were generated using the CRISPR-Cas9 system. Embryos from the 4-cell stage to the morula stage were collected and treated with acidic Tyrode's solution to remove the zona pellucida. We used 50 embryos per sample at each developmental stage and identified the proteome of mouse Wdr74-knockout embryos by label-free quantification.

2025-05-22 | PXD059124 | JPOST Repository

Proteome analysis of mouse oocytes and pre-implantation embryos

Project description:Mouse oocytes and embryos from the germinal vesicle (GV) stage to the blastocyst stage were collected and treated with acidic Tyrode’s solution to remove the zona pellucida. We used 42.5 oocytes or embryos per sample at each developmental stage and identified the proteome during mouse pre-implantation development by label-free quantification.

2025-05-22 | PXD059122 | JPOST Repository

Expression data from mouse preimplantation cloned embryos

Project description:Transcriptiome analysis is an excellent approach to understand the mechanism underlying nuclear reprogramming in somatic-cell-cloned embryos. Analysis of the transcriptomic data from the oocyte to blastocyst stage revealed that specific genes were inappropriately reprogrammed at each stage. Sertoli cell-cloned embryos appear to develop normally because the progression of incorrect reprogramming is concealed throughout development. The time-lapse gene expression profiles provide valuable information for understanding reprogramming in SCNT embryos. Single mouse oocyte (MII metaphase), in vitro fertilized embryo (replicates = 3 / each stage) and Sertoli cell cloned embryo (replicates = 5 / each stage) from 1-cell stage to blastocyst stage (16, 32, 48, 62, 72, 84 hours after sperm addition or activation) was used for total RNA extraction. Totally 51 Affymetrix microarrays were used in the experiment.

2013-04-05 | E-GEOD-41358 | biostudies-arrayexpress

Pollution Effects on Sensitive and Resistant Embryos: Integrating Structure and Function with Gene Expression

Project description:To explore how gene expression translates to developmental phenotype in both sensitive and resistant Fundulus embryos upon POP exposure, we exposed Fundulus embryos from the Elizabeth River Superfund population and the Magotha Bay, VA clean population to Elizabeth River polluted sediment extracts and measured chemical uptake, gene expression, and altered embryo anatomy, morphology and cardiac physiology during four critical developmental stages: somitogenesis, heart beat initiation, late organogenesis, and pre-hatching.

2019-05-07 | GSE130754 | GEO

Quantitative proteomes of Imp2 KO mouse 2-cell-stage embryos

Project description:Data showing the late 2-cell-stage, control embryos (Imp2♀+/♂+) and Imp2-knockout embryos (Imp2♀−/♂+) for HPLC MS/MS analysis. 3 replicates were performed using 330 embryos per group.

2019-11-12 | PXD010397 | Pride

Single cell analysis for oocytes and early embryos

Project description:While non-mammalian embryos often rely on spatial pre-patterning, for decades it was believed that blastomeres of mouse and human embryos were developmentally equivalent. However, emerging evidence suggests early mouse and human blastomeres differ in developmental potential. Here, using multiplexed and label-free single-cell proteomics, we identify over three hundred asymmetrically abundant proteins - many involved in protein degradation and transport - that divide mouse 2-cell stage blastomeres into two distinct clusters, which we term alpha and beta. These asymmetries intensify at the 4-cell stage and are detectable as early as the zygote. Fertilisation acts as a trigger for this breaking of symmetry and sperm entry point correlates with the gradient of proteome asymmetry. Perturbation of beta-enriched proteins (Gps1, Nedd8) alters lineage segregation. Embryos derived from beta blastomeres have more epiblast cells, while alpha blastomeres are associated with a lower developmental potential. Human 2-cell embryos show similar clustering and enrichment patterns, supporting conservation of this early asymmetry. Our findings reveal a previously unrecognized proteomic pre-patterning triggered by fertilisation in mammalian embryos, with implications for understanding totipotency and early lineage bias.

2025-08-10 | MSV000098778 | MassIVE

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data