Shared αβ T Cell Receptor Usage in Lungs of Sarcoidosis Patients with Löfgren’s Syndrome [ePCR]

ABSTRACT: Expansions of CD4+ T cells utilizing TRAV12-1/TRBV2 were found exclusively in HLA-DR3+ LS patients. These TCRs shared CDR3 homology, suggesting that these T cells are responsible for recognizing sarcoidosis-associated antigen(s) and are involved in the local alveolitis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100556 | GEO | 2017/07/21

SECONDARY ACCESSION(S): PRJNA392107

REPOSITORIES: GEO