Dataset Information


RNA-seq analysis of genes under control of Burkholderia thailandensis E264 MftR

ABSTRACT: Comparison of transcriptomes of wild-type cells and cells deleted for MftR as well as both strain grown in absence and presence of 5 mM urate Overall design: Four different samples, each analyzed in triplicate

INSTRUMENT(S): Illumina HiSeq 2500 (Burkholderia thailandensis)

SUBMITTER: Anne Grove  

PROVIDER: GSE100659 | GEO | 2017-12-15



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Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.

Gupta Ashish A   Bedre Renesh R   Thapa Sudarshan Singh SS   Sabrin Afsana A   Wang Guannan G   Dassanayake Maheshi M   Grove Anne A  

ACS chemical biology 20171108 12

Many bacteria encode biosynthetic proteins that produce a vast array of natural products. These compounds are often synthesized during host invasion as they function as virulence factors. In addition, such secondary metabolites have yielded numerous molecular scaffolds with pharmaceutical and clinical importance. The gene clusters that encode proteins responsible for synthesis of these compounds are typically silenced or "cryptic" under laboratory growth conditions, hampering discovery of novel  ...[more]

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