Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq analysis of genes under control of Burkholderia thailandensis E264 MftR

ABSTRACT: Comparison of transcriptomes of wild-type cells and cells deleted for MftR as well as both strain grown in absence and presence of 5 mM urate

ORGANISM(S): Burkholderia thailandensis

PROVIDER: GSE100659 | GEO | 2017/12/15

SECONDARY ACCESSION(S): PRJNA392446

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcriptional of Burkholderia thailandensis E264 and Burkholderia thailandensis BPM

Project description:To explore the expression differences between the two strains

2021-02-15 | GSE147369 | GEO

FK228 from Burkholderia thailandensis MSMB43.

Project description: Not available

| S-EPMC3435793 | biostudies-other

Regulation of Choline Catabolism in Burkholderia thailandensis

Project description:Burkholderia thailandensis is a soil-dwelling bacterium that shares many metabolic pathways with the ecologically similar, but evolutionarily distant, Pseudomonas aeruginosa. Among the diverse nutrients it can utilize is choline, which can be converted into the osmoprotectant glycine betaine and further catabolized as a source of carbon and nitrogen, similar to P. aeruginosa. Orthologs of genes in the choline catabolic pathway in these two bacteria showed distinct differences in gene arrangement as well as an additional orthologous transcriptional regulator in B. thailandensis. In this study, we showed that multiple glutamine amidotransferase1 (GATase1)-containing AraC-family transcription regulators (GATRs) are involved in regulation of the B. thailandensis choline catabolic pathway (gbdR1, gbdR2, souR). Using genetic analyses and sequencing the transcriptome in the presence and absence of choline, we identified the likely regulons of gbdR1 (BTH_II1869) and gbdR2 (BTH_II0968). We also identified a functional ortholog for P. aeruginosa souR, a GATR that regulates the metabolism of sarcosine to glycine. GbdR1 is absolutely required for expression of the choline catabolic locus, similar to P. aeruginosa GbdR, while GbdR2 is important to increase expression of the catabolic locus. Additionally, the B. thailandensis SouR ortholog (BTH_II0994) is required for catabolism of choline and its metabolites as carbon sources, whereas in P. aeruginosa, SouR function can by bypassed by GbdR. The strategy employed by B. thailandensis represents a distinct regulatory solution to control choline catabolism and thus provides both an evolutionary counterpoint and an experimental system to compare the acquisition and regulation of this pathway during environmental growth and infection.

2016-07-12 | GSE81652 | GEO

CEA SGF:E00013#yap1 aft W303a HU response

Project description:Analysis of the response to hydroxyurea in a yeast aft1 mutant strain compared to wild-type strain (BY4741 or BY4742 backgrounds). Cells were grown in YPD rich medium containong 200 mM hydroxyurea (HU) for 2 hours. Analysis of the response to hydroxyurea in a yeast aft1aft2 mutant strain (Y18aft2d) compared to wild-type strain (CM3260). Cells were grown in YPD rich medium containing 200 mM hydroxyurea (HU) for 2 hours. Gene expression changes due to the aft1 mutation were also analysed in absence of HU (BY4741 background). Analysis of mid-term response to hydroxyurea in a yeast wild-type strain (W303a). Cells were grown in YPD rich medium containing 200 mM hydroxyurea (HU) for 2 hours. Gene expression changes were analysed compared to the same strain grown in the same medium without HU. Keywords: repeat sample

2005-12-01 | GSE1914 | GEO

Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis.

Project description: Not available

| S-EPMC3103185 | biostudies-other

Histone deacetylase inhibitors from Burkholderia thailandensis.

Project description: Not available

| S-EPMC3204006 | biostudies-literature

Competition between Burkholderia pseudomallei and B. thailandensis.

Project description: Not available

| S-EPMC4365494 | biostudies-literature

Human Infection with Burkholderia thailandensis, China, 2013.

Project description: Not available