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Gene expression data from murine liver samples comparing hormone sensitive lipase (HSL) knockout mice vs. wildtype mice

ABSTRACT: HSL is a key enzyme in in the mobilization of fatty acids from the triglyceride stores of white adipose tissue. In addition, it is expressed in mice liver. In the present microarray study, changes in the transcript profile of murine liver samples due to global HSL knockout were investigated. Keywords: genetic modification

ORGANISM(S): Mus musculus

PROVIDER: GSE10067 | GEO | 2009/01/03

SECONDARY ACCESSION(S): PRJNA108173

REPOSITORIES: GEO

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Transcription profiling of mouse liver samples comparing hormone sensitive lipase (HSL) knockout mice vs. wildtype

Project description:HSL is a key enzyme in in the mobilization of fatty acids from the triglyceride stores of white adipose tissue. In addition, it is expressed in mice liver. In the present microarray study, changes in the transcript profile of murine liver samples due to global HSL knockout were investigated. Experiment Overall Design: Genetic modification to analyze the impact of a general knockout of the HSL gene on liver metabolism. Experiment Overall Design: HSL knockout (ko) mice versus wildtype (wt) mice. Mice fed a normal diet (ND) versus mice fed a high fat diet (FD) for 6 months. Equal amounts of liver samples from six mice were pooled and total RNA was extracted, except for HSL-null mice on FD were only 4 livers were pooled.

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Effect of rosiglitazone on adipose gene expression in HSL knockout mice with different diet treatment

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