Genomics

Dataset Information

0

Transcriptome analysis of FKBP25 siRNA-knockdown in cultured HEK 293 cells


ABSTRACT: Peptidyl-prolyl isomerases (PPIs) are a superfamily of ubiquitous enzymes that catalyze the cis-trans interconversion of Xaa-Pro peptide bonds. The functions of most PPIs remain uncharacterized. FKBP25, a mammalian PPI, localizes to the nucleus, binds nucleic acids, and associates with chromatin modifying enzymes. However, the role of this protein in transcriptional regulation remains unclear. To help address this question we present RNA-seq gene expression profiling in HEK293 cells transfected with siRNA targeting FKBP25 relative to a GFP-targeting negative control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100813 | GEO | 2018/01/03

SECONDARY ACCESSION(S): PRJNA393164

REPOSITORIES: GEO

Similar Datasets

2018-11-27 | GSE109237 | GEO
2018-05-01 | GSE110809 | GEO
2020-03-20 | GSE144092 | GEO
| S-EPMC2793268 | biostudies-literature
| S-EPMC3832390 | biostudies-literature
2021-01-28 | PXD023811 | Pride
| S-EPMC5241390 | biostudies-literature
| S-EPMC7462251 | biostudies-literature
| S-EPMC7550284 | biostudies-literature
| S-EPMC4196569 | biostudies-literature