Transcriptomics,Genomics

Dataset Information

149

Primary spinal OPC culture system from adult zebrafish to study oligodendrocyte differentiation in vitro


ABSTRACT: Endogenous oligodendrocyte progenitor cells (OPCs) are a promising target to improve functional recovery after spinal cord injury (SCI) by remyelinating denuded, and therefore vulnerable, axons. Demyelination is the result of a primary insult and secondary injury, leading to conduction blocks and long-term degeneration of the axons, which subsequently can lead to the loss of their neuron. In response to SCI, dormant OPCs can be activated and subsequently start to proliferate and differentiate into mature myelinating oligodendrocytes (OLs). Therefore, researchers strive to control OPC responses, and utilize small molecule screening approaches in order to identify mechanisms of OPC activation, proliferation, migration and differentiation. Overall design: DEG analysis of primary OPC and OL populations, 5 biological replicates per population

INSTRUMENT(S): Illumina HiSeq 2500 (Danio rerio)

SUBMITTER: Michell M Reimer  

PROVIDER: GSE100821 | GEO | 2017-09-05

SECONDARY ACCESSION(S): PRJNA393181

REPOSITORIES: GEO

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Publications

Primary Spinal OPC Culture System from Adult Zebrafish to Study Oligodendrocyte Differentiation In Vitro.

Kroehne Volker V   Tsata Vasiliki V   Marrone Lara L   Froeb Claudia C   Reinhardt Susanne S   Gompf Anne A   Dahl Andreas A   Sterneckert Jared J   Reimer Michell M MM  

Frontiers in cellular neuroscience 20170914


Endogenous oligodendrocyte progenitor cells (OPCs) are a promising target to improve functional recovery after spinal cord injury (SCI) by remyelinating denuded, and therefore vulnerable, axons. Demyelination is the result of a primary insult and secondary injury, leading to conduction blocks and long-term degeneration of the axons, which subsequently can lead to the loss of their neurons. In response to SCI, dormant OPCs can be activated and subsequently start to proliferate and differentiate i  ...[more]

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