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Time course of MEK inhibition

ABSTRACT: This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a representative V600E BRAF cell line as a function of time following exposure to a small molecule inhibitor of MEK. Keywords: Time course

ORGANISM(S): Homo sapiens

PROVIDER: GSE10088 | GEO | 2009/02/11

SECONDARY ACCESSION(S): PRJNA108973

REPOSITORIES: GEO

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Transcription profiling of human SkMel-28 cells growing in culture treated with the MEK inhibitor PD0325901 for 2, 8, or 24 hours time course of MEK inhibition

Project description:This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a representative V600E BRAF cell line as a function of time following exposure to a small molecule inhibitor of MEK. Experiment Overall Design: SkMel-28 cells growing in culture were treated with the MEK inhibitor PD0325901 for 2, 8, or 24 hours. Changes in RNA compared to reference (time =0) were measured using microarray analysis.

2009-02-21 | E-GEOD-10088 | biostudies-arrayexpress

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2009-02-21 | E-GEOD-10087 | biostudies-arrayexpress

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2009-02-11 | GSE10087 | GEO

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2014-12-12 | E-GEOD-63790 | biostudies-arrayexpress

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