DYRK2 stabilization has dual effects on apoptosis and self-renewal of leukemia stem cells that can be targeted in chronic myeloid leukemia

ABSTRACT: Gene expression analysis of leukemic stem cells (LSC) from WT and KLF4-deficient BCR-ABL p210-induced chronic myeloid leukemia (CML) mice Loss of Klf4 impairs self-renewal and survival of LSC in CML. Analysis provides insight into function of KLF4 in leukemia.

ORGANISM(S): Mus musculus Mus

PROVIDER: GSE100909 | GEO | 2018/12/31

REPOSITORIES: GEO