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Hepatic lipid metabolism in chicken lines divergently selected for abdominal fat content

ABSTRACT: We performed gene expression profiling on chicken livers at five important embryonic developmental stages (E7, E12, E14, E17 and E21), which were selected from chicken lines with significant differences in abdominal fat content. Each developmental stage had its unique gene expression pattern and stage-specific differentially expressed genes (DEGs). Furthermore, the three rapid growth periods (E12, E14 and E17) had similar expression patterns. Between the two broiler lines, E17 had the largest number of significantly differentially expressed genes (979), specifically enriched in fatty acid metabolism and biosynthesis, PPAR signaling and glycolysis pathways. Therefore, genome-wide gene expression recapitulated the developmental pattern of chicken embryos, and found the important molecular pathways for hepatic lipid metabolism.

ORGANISM(S): Gallus gallus

PROVIDER: GSE101182 | GEO | 2018/06/04

REPOSITORIES: GEO

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