C-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification (ChIP-Seq)

ABSTRACT: Childhood neuroblastoma is known for MYCN gene amplification, and here we show that in a separate subset of cases MYC-itself is activated due to enhancer hijacking from chromosomal translocations or duplications, thus defining a unique subset of high-risk disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101295 | GEO | 2017/12/22

SECONDARY ACCESSION(S): PRJNA398586

REPOSITORIES: GEO