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Genome-wide analysis of prostatic tissue gene expression from patients with benign prostatic hyperplasia

ABSTRACT: Analysis of gene expression in prostatic tissue from BPH patients with and without SRD5A2 gene methylation. The hypothesis is that BPH patients with DNA methylation of the SRD5A2 gene promoter have impaired conversion of testosterone to dihydrotestosterone, and therefore may use an alternative signaling pathway for prostatic tissue growth. Here, we compare gene expression profiles of SRD5A2-methylated vs. unmethylated prostatic tissue to nominate alternative biological pathways relevant in each molecular subtype of BPH. Overall design: 22 unique patient samples were analyzed (12 SRD5A2-methylated, 10 SRD5A2-unmethylated). All samples were transitional zone prostatic tissue obtained during transurethral resection of prostate (TURP) surgery.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Keyan Salari  

PROVIDER: GSE101486 | GEO | 2017-10-01



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Androgenic to oestrogenic switch in the human adult prostate gland is regulated by epigenetic silencing of steroid 5α-reductase 2.

Wang Zongwei Z   Hu Libing L   Salari Keyan K   Bechis Seth K SK   Ge Rongbin R   Wu Shulin S   Rassoulian Cyrus C   Pham Jonathan J   Wu Chin-Lee CL   Tabatabaei Shahin S   Strand Douglas W DW   Olumi Aria F AF  

The Journal of pathology 20171201 4

Benign prostatic hyperplasia is the most common proliferative abnormality of the prostate. All men experience some prostatic growth as they age, but the rate of growth varies among individuals. Steroid 5α-reductase 2 (SRD5A2) is a critical enzyme for prostatic development and growth. Previous work indicates that one-third of adult prostatic samples do not express SRD5A2, secondary to epigenetic modifications. Here we show that the level of oestradiol is dramatically elevated, concomitant with si  ...[more]

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